As the proton beam interacts in the patient, positron emitting radioisotopes and prompt gammas will be created in vivo and can be monitored to verify the therapy. Dose delivery can be monitored in vivo by PET or prompt gamma imaging (PGI) systems. ![]() The consequence is that the delivered high dose region is less conformal to the target and more healthy tissue may receive full dose. To ensure that the target is adequately covered, the maximum range is increased by nominally 3.5% of the maximum depth plus 1 mm. ![]() The main uncertainties are related to proton range. Modern proton therapy gantries can deliver accurate dose (☑%) to a precise target location (☑–2 mm).
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